MovDisordV3, Ncbi, Merge, bibRecord, 004D22

[123I]beta-CIT single-photon emission tomography in DOPA-responsive dystonia.

Identifieur interne : 004D22 ( Ncbi/Merge ); précédent : 004D21; suivant : 004D23

[123I]beta-CIT single-photon emission tomography in DOPA-responsive dystonia.

Auteurs : M. Naumann [Allemagne] ; W. Pirker ; K. Reiners ; K. Lange ; G. Becker ; T. Brücke

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1997.

RBID : pubmed:9159746

English descriptors

KwdEn :
- Adult, Aged, Binding Sites, Cerebellum (metabolism), Cerebellum (radionuclide imaging), Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Diagnosis, Differential, Dopamine (metabolism), Dystonia (drug therapy), Dystonia (radionuclide imaging), Female, Humans, Levodopa (therapeutic use), Middle Aged, Radioactive Tracers, Tomography, Emission-Computed, Single-Photon.
MESH :
- chemical , metabolism : Dopamine.
- drug therapy : Dystonia.
- metabolism : Cerebellum, Corpus Striatum.
- radionuclide imaging : Cerebellum, Corpus Striatum, Dystonia.
- chemical , therapeutic use : Levodopa.
- Adult, Aged, Binding Sites, Diagnosis, Differential, Female, Humans, Middle Aged, Radioactive Tracers, Tomography, Emission-Computed, Single-Photon.

Abstract

The radiotracer [123I]beta-CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [123I]beta-CIT single-photon emission computed tomography (SPECT) findings in a patient with DOPA-responsive dystonia (DRD). [123I]beta-CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile-onset parkinsonism with dystonia that have a considerable poorer prognosis. [123I]-beta-CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.

DOI: 10.1002/mds.870120330
PubMed: 9159746

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pubmed:9159746

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[123I]beta-CIT single-photon emission tomography in DOPA-responsive dystonia.</title>
<author><name sortKey="Naumann, M" sort="Naumann, M" uniqKey="Naumann M" first="M" last="Naumann">M. Naumann</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Universities of Würzburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Universities of Würzburg</wicri:regionArea>
<wicri:noRegion>Universities of Würzburg</wicri:noRegion>
<wicri:noRegion>Universities of Würzburg</wicri:noRegion>
<wicri:noRegion>Universities of Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pirker, W" sort="Pirker, W" uniqKey="Pirker W" first="W" last="Pirker">W. Pirker</name>
</author>
<author><name sortKey="Reiners, K" sort="Reiners, K" uniqKey="Reiners K" first="K" last="Reiners">K. Reiners</name>
</author>
<author><name sortKey="Lange, K" sort="Lange, K" uniqKey="Lange K" first="K" last="Lange">K. Lange</name>
</author>
<author><name sortKey="Becker, G" sort="Becker, G" uniqKey="Becker G" first="G" last="Becker">G. Becker</name>
</author>
<author><name sortKey="Brucke, T" sort="Brucke, T" uniqKey="Brucke T" first="T" last="Brücke">T. Brücke</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[123I]beta-CIT single-photon emission tomography in DOPA-responsive dystonia.</title>
<author><name sortKey="Naumann, M" sort="Naumann, M" uniqKey="Naumann M" first="M" last="Naumann">M. Naumann</name>
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<author><name sortKey="Pirker, W" sort="Pirker, W" uniqKey="Pirker W" first="W" last="Pirker">W. Pirker</name>
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<author><name sortKey="Reiners, K" sort="Reiners, K" uniqKey="Reiners K" first="K" last="Reiners">K. Reiners</name>
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<author><name sortKey="Lange, K" sort="Lange, K" uniqKey="Lange K" first="K" last="Lange">K. Lange</name>
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<author><name sortKey="Becker, G" sort="Becker, G" uniqKey="Becker G" first="G" last="Becker">G. Becker</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Binding Sites</term>
<term>Cerebellum (metabolism)</term>
<term>Cerebellum (radionuclide imaging)</term>
<term>Corpus Striatum (metabolism)</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>Diagnosis, Differential</term>
<term>Dopamine (metabolism)</term>
<term>Dystonia (drug therapy)</term>
<term>Dystonia (radionuclide imaging)</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Middle Aged</term>
<term>Radioactive Tracers</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebellum</term>
<term>Corpus Striatum</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebellum</term>
<term>Corpus Striatum</term>
<term>Dystonia</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Binding Sites</term>
<term>Diagnosis, Differential</term>
<term>Female</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Radioactive Tracers</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
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<front><div type="abstract" xml:lang="en">The radiotracer [123I]beta-CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [123I]beta-CIT single-photon emission computed tomography (SPECT) findings in a patient with DOPA-responsive dystonia (DRD). [123I]beta-CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile-onset parkinsonism with dystonia that have a considerable poorer prognosis. [123I]-beta-CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.</div>
</front>
</TEI>
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<DateCreated><Year>1997</Year>
<Month>07</Month>
<Day>28</Day>
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<DateCompleted><Year>1997</Year>
<Month>07</Month>
<Day>28</Day>
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<DateRevised><Year>2013</Year>
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<Issue>3</Issue>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>[123I]beta-CIT single-photon emission tomography in DOPA-responsive dystonia.</ArticleTitle>
<Pagination><MedlinePgn>448-51</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The radiotracer [123I]beta-CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [123I]beta-CIT single-photon emission computed tomography (SPECT) findings in a patient with DOPA-responsive dystonia (DRD). [123I]beta-CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile-onset parkinsonism with dystonia that have a considerable poorer prognosis. [123I]-beta-CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Naumann</LastName>
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<AffiliationInfo><Affiliation>Department of Neurology, Universities of Würzburg, Germany.</Affiliation>
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	Movement Disorders (revue)
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Movement Disorders (revue)

[123I]beta-CIT single-photon emission tomography in DOPA-responsive dystonia.

[123I]beta-CIT single-photon emission tomography in DOPA-responsive dystonia.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki